Telomere length, family history, and paternal age in schizophrenia
نویسندگان
چکیده
منابع مشابه
Telomere length, family history, and paternal age in schizophrenia
Leukocyte telomere length (LTL) is longer in association with advanced paternal age, but this association has not been examined along with family history (FH) in schizophrenia. LTL was measured by PCR and compared across cases and controls as part of a study to examine the characteristics of paternal age related schizophrenia. The 53 schizophrenia cases had similar mean LTL as 20 controls, alth...
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Telomere length (TL) in humans is highly heritable and undergoes progressive age-dependent shortening in somatic cells. By contrast, sperm donated by older men display comparatively long telomeres, presumably because in the male germline, telomeres become longer with age. This puzzling phenomenon might explain why TL in the offspring correlates positively with paternal age. The present communic...
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Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We explored the relation between paternal age and offspring's LTLs in 4 different cohorts. Moreover, we examined the potential cause of the paternal age on offspring's LTL by deli...
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Telomere length, a highly heritable trait, is longer in offspring of older fathers. This perplexing feature has been attributed to the longer telomeres in sperm of older men and it might be an 'epigenetic' mechanism through which paternal age plays a role in telomere length regulation in humans. Based on two independent (discovery and replication) twin studies, comprising 889 twin pairs, we sho...
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Telomeres are repeating sequences of DNA found at the ends of chromosomes, that shorten in most proliferating tissues as we age and our cells replicate. Shortened telomeres result in a reduced capacity for cell proliferation, and in adults have been shown to predict increased morbidity and earlier mortality. Whereas telomeres tend to shorten with cell replications in most tissues, sperm telomer...
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ژورنال
عنوان ژورنال: Molecular Genetics & Genomic Medicine
سال: 2014
ISSN: 2324-9269,2324-9269
DOI: 10.1002/mgg3.71